Apoquel® (oclacitinib tablet) Efficacy

Fast and effective

Apoquel is the #1 prescribed medicine for allergic itch and is effective for1-3:

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Flea allergy

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Food allergy

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Atopic dermatitis

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Contact allergy

Apoquel began to control allergic itch within 4 hours

Apoquel delivered fast relief that began to control itch within 4 hours, comparable to oral steroids, in dogs with allergic dermatitis4,5

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*The dose of prednisolone was lowered at Day 6 to account for the real-world dosing scenario of prednisolone.

Apoquel provided significant reduction in skin inflammation due to allergic dermatitis

Apoquel leads to significant reduction in skin inflammation over the long term6,7:

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Controls inflammation due to allergic dermatitis and atopic dermatitis4,6,8,9

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Controls pruritus due to allergic dermatitis and atopic dermatitis4,6,8,9

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Reduces clinical signs of inflammation due to allergic dermatitis comparable to steroids4,5

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Controls inflammation due to allergic dermatitis and atopic dermatitis4,6,8,9

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Controls pruritus due to allergic dermatitis and atopic dermatitis4,6,8,9

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Reduces clinical signs of inflammation due to allergic dermatitis comparable to steroids4,5

Apoquel was shown to be as effective as steroids in reducing skin inflammation due to allergic dermatitis at all time points4,5

Real-world results10

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BEFORE APOQUEL

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AFTER 48 HOURS OF APOQUEL

Marley

Boston Terrier Mix

Age: 5 years

30 lb

Additional Study Results

Apoquel controlled allergic itch within 24 hours8

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Apoquel provided significant long-term itch relief6,7

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Apoquel exhibited faster onset of relief than ATOPICA® (cyclosporine capsules, USP) in the control of pruritus in dogs with atopic dermatitis9,11

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References: 1. Data on file, Monthly Vetstreet Report, December 2019, Zoetis Inc. 2. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047. 3. Moriello KA. Canine allergic dermatitis: pathogenesis, clinical signs, and diagnosis. DVM 360. May 31, 2006. Accessed June 29, 2020. https://www.dvm360.com/view/canine-allergic-dermatitis-pathogenesis-clinical-signs-and-diagnosis. 4. Gadeyne C, Little P, King VL, et al. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-e86. doi:10.1111/vde.12166. 5. Data on file, Study No. A161R-AU-12-096, Zoetis Inc. 6. Cosgrove SB, Wren JA, Cleaver DM, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013;24(6):587-e142. doi:10.1111/vde.12088. 7. Data on file, Study No. 1962C-60-10-A16, Zoetis Inc.  8. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047. 9. Little PR, King VL, Davis KR, et al. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015;26(1):23-e8. doi:10.1111/vde.12186. 10. Data on file, Pet Owner Case Study–Marley, Zoetis Inc. 11. Data on file, Study No. 6962R-14-10-025, Zoetis Inc. 

Apoquel Indications

Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Apoquel Important Safety Information

Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

Apoquel Indications

Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Apoquel Important Safety Information

Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.