Apoquel works differently
Apoquel is the first medicine specifically designed to target canine itch and inflammation due to allergic and atopic dermatitis1,2
Works differently from steroids and cyclosporines2-4
Nonsteroidal Apoquel targets specific cytokines that cause itch and inflammation, relieving symptoms of allergic skin disease with minimal impact on the immune system5
- Works differently from steroids and cyclosporines2-4
- Nonsteroidal Apoquel targets specific cytokines that cause itch and inflammation, relieving symptoms of allergic skin disease with minimal impact on the immune system5
JAK1 and JAK3 inhibition
Inhibits the function of a variety of pruritogenic and proinflammatory cytokines
Minimal effect on JAK2
With minimal effect on JAK2-dependent cytokines involved in hematopoiesis and innate immunity
Apoquel controls allergic itch with minimal effects on the immune system5
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References: 1. Marsella R, Doerr K, Gonzales A, Rosenkrantz W, Schissler J, White A. Oclacitinib 10 years later: lessons learned and directions for the future. J Am Vet Med Assoc. 2023;261(S1):S36-S47. doi:10.2460/javma.22.12.0570 2. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (Apoquel®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317-324. doi:10.1111/jvp.12101 3. Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13. doi:10.1016/j.mce.2010.04.005 4. Guaguère E, Steffan J, Olivry T. Cyclosporin A: a new drug in the field of canine dermatology. Vet Dermatol. 2004;15(2):61-74. doi:10.1111/j.1365-3164.2004.00376.x 5. Banovic F, Tarigo J, Gordon H, Barber JP, et al. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Vet Dermatol. 2019;30(1):17-e6. doi:10.1111/vde.12698
Cytopoint Indications
Cytopoint has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis.
Apoquel and Apoquel Chewable Indications
Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Apoquel and Apoquel Chewable Important Safety Information
Do not use Apoquel or Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel and Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel and Apoquel Chewable have not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel and Apoquel Chewable have been used safely with many common medications including parasiticides, antibiotics and vaccines.
See full Prescribing Information for Apoquel and full Prescribing Information for Apoquel Chewable.